Ex Parte ETCHEVERRY et al - Page 1

                            The opinion in support of the decision being entered today was not written                  
                                   for publication and is not binding precedent of the Board.                           
                                                                                           Paper No. 28                 
                         UNITED STATES PATENT AND TRADEMARK OFFICE                                                      
                                                     __________                                                         
                              BEFORE THE BOARD OF PATENT APPEALS                                                        
                                             AND INTERFERENCES                                                          
                                                     __________                                                         
                                 Ex parte TINA ETCHEVERRY and THOMAS RYLL                                               
                                                     __________                                                         
                                                Appeal No. 2002-0872                                                    
                                             Application No. 08/470,849                                                 
                                                     __________                                                         
                                                      ON BRIEF                                                          
                                                     __________                                                         
              Before SCHEINER, ADAMS and MILLS, Administrative Patent Judges.                                           
              ADAMS, Administrative Patent Judge.                                                                       
                                               DECISION ON APPEAL                                                       
                     This is a decision on the appeal under 35 U.S.C. § 134 from the examiner’s final                   
              rejection of claims 18-23.  The only other pending claim (claim 24) was objected to as                    
              dependent upon a rejected base claim and was not included as part of this appeal.                         
                     Claims 18 and 20 are illustrative of the subject matter on appeal and are                          
              reproduced below:                                                                                         
                     18. A human TNFR1-IgG1 preparation comprising TNFR1-IgG1 prepared by a                             
                          process comprising:                                                                           
                            (a) culturing a mammalian dp12.CHO host cell which expresses a human                        
                               TNFR1-IgG1 chimera in a growth phase under such conditions and for                       
                               a period of time such that maximum cell growth is achieved;                              
                            (b) culturing the host cell in a production phase:                                          
                                     (1) in the presence of sodium butyrate at a concentration of about                 
                                        1 mM to about 6 mM;                                                             
                                     (2) at an osmolality of about 350-450 mOsm; and                                    
                                     (3) at a temperature about between 30°C and 35°C.                                  







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