Ex Parte Jacobs et al - Page 6

              Appeal 2007-0539                                                                     
              Application 10/264,026                                                               

                    Ghisalberti describes a tricyclic diterpene containing the 3-epi-              
              pseudopterosin skeleton, isolated from an extract of the terrestrial plant           
              Eremophila serrulata.  The 3-epi-pseudopterosin skeleton is also found in            
              sponges, and “[m]ore examples have [ ] been found in the pseudopterosins, a          
              class of anti-inflammatory and analgesic diterpene glycosides, produced by           
              the marine octocoral Pseudopterogorgia elisabethae” (Ghisalberti 2169).              
              According to Ghisalberti, the tricyclic diterpene from E. serrulata is “a            
              3-epimer of the aglycone derived from the pseudopterosins isolated from the          
              Bahamas collection of P. elisabethae” (id.).                                         
                    Roussis describes anti-inflammatory pseudopterosins A-L, at least one          
              of which was pure enough to crystallize, isolated from extracts of P.                
              elisabethae (Roussis 4918, left-hand col.).                                          
                    Look describes seco-pseudopterosins with anti-inflammatory and                 
              analgesic activities, isolated from a Caribbean sea whip of the genus                
              Pseudopterogorgia (Look 3363).  “Specimens of Pseudopterogorgia . . .                
              were extracted with chloroform and ethyl acetate.  The combined extracts             
              were chromatographed over TLC grade silica gel and fractions containing              
              polar compounds were further fractionated by silica HPLC.  Purification              
              yielded the seco-pseudopterosins A-D (1-4) as the major components of the            
              extract” (id. at 3365).                                                              
                    Mohammadi describes cosmetic compositions containing gorgonian                 
              extract in a crosslinked silicone elastomer base (Mohammadi col. 1, l. 58 to         
              col. 2, l. 6).                                                                       
                    The Examiner’s position is that “[t]he pseudopterosin compositions of          
              the instant claims are not . . . patentably distinct from those of the prior art”    


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