Ex Parte Cuthbertson et al - Page 3

                Appeal No. 2007-1140                                                                         
                Application No. 10/753,729                                                                   

                   Cuthbertson et al. (Cuthbertson)    PCT WO 01/77145 A2    Oct. 18,                        
                2001Co-pending U.S. App. Ser. No. 10/269, 575 (“the ‘575 Application”)                       
                   Claims 1-11, 13-18, 20, and 22 stand rejected under 35 U.S.C. § 103(a)                    
                as obvious over Cuthbertson (Answer 4).  Claims 1-11, 13-18, 20, and 22                      
                stand provisionally rejected under the judicially-created doctrine of obvious-               
                type double patent as unpatentable over claims 1-22 of the co-pending ‘575                   
                Application (Answer 7).  The claims stand or fall together in each rejection                 
                because Appellants did not argue separately argue the patentability of the                   
                claims.  For the purpose of deciding this appeal, we chose claim 1 as                        
                representative.  See 37 C.F.R. § 41.37(c)(1)(vii).  Claim 1 reads as follows:                

                      1.  A compound of general formula (I)                                                  







                      or pharmaceutically acceptable salt thereof wherein                                    
                      G represents glycine                                                                   
                      D represents aspartic acid                                                             
                      R1 represents -(CH2)n,- or -(CH2)n-C6H4- wherein                                       
                      n represents a positive integer 1 to 10                                                
                      h represents a positive integer 1 or 2                                                 
                      X1 represents an amino acid residue wherein said amino acid                            
                      possesses a functional side-chain such as an acid or amine.                            
                      X2 and X4 represent independently an amino acid residue capable of                     
                      forming a disulphide bond,                                                             
                      X3 represents arginine, N-methylarginine or an arginine mimetic,                       
                      X5 represents a hydrophobic amino acid or derivatives thereof, and                     

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