Ex Parte Crea - Page 3

                Appeal  2007-2400                                                                            
                Application  10/418,182                                                                      

                      individually; and then through each of the possible                                    
                      combinatorial variations of the CDRs (pairs, triad, tetrads, etc.).                    
                (Id. at 15-16.)                                                                              
                      The libraries are disclosed to be useful as research tools (id. at 17-18).             
                                               DISCUSSION                                                    
                1.  CLAIMS                                                                                   
                      Claims 1-9 are pending and on appeal.  The claims have not been                        
                argued separately and therefore stand or fall together.  37 C.F.R.                           
                § 41.37(c)(1)(vii) (2006).  Claim 1 is representative and reads as follows:                  
                1.  A library for an immunoglobulin of interest, comprising mutated                          
                immunoglobulins of interest wherein a single predetermined amino acid has                    
                been substituted in at least one position in at least one complementarity-                   
                determining region of the immunoglobulin of interest, the library including                  
                subset libraries comprising:                                                                 
                a) a subset library comprising the immunoglobulin of interest,                               
                b)  subset libraries comprising mutated immunoglobulins in which the                         
                      predetermined amino acid has been substituted in at least one position                 
                      in one of the six complementarity-determining regions of the                           
                      immunoglobulin, with one subset library for each of the six                            
                      complementarity-determining regions, thereby totaling 6 subset                         
                      libraries;                                                                             
                c)  subset libraries comprising mutated immunoglobulins in which the                         
                      predetermined amino acid has been substituted in at least one position                 
                      in two of the six complementarity-determining regions, with one                        
                      subset library for each of the possible combinations of two of the six                 
                      complementarity-determining regions, thereby totaling 15 subset                        
                      libraries;                                                                             
                d) subset libraries comprising mutated immunoglobulins in which the                          
                      predetermined amino acid has been substituted in at least one position                 
                      in three of the six complementarity-determining regions, with one                      

                                                     3                                                       

Page:  Previous  1  2  3  4  5  6  7  8  9  10  11  12  13  Next

Last modified: September 9, 2013