Ex parte MANO et al. - Page 5




                Appeal No. 95-4448                                                                                                       
                Application 08/070,434                                                                                                   


                conalbumin, let alone a chemically modified conalbumin which functions as a chiral resolving agent.                      

                Moreover, the examiner has not explained why a person having ordinary                                                    





                skill in the art would have been motivated by the teachings of the prior art to chemically modify conalbumin.            

                In addition, the examiner is relying on the prior art teachings of Miwa to equate conalbumin and bovine                  

                serum albumin as equivalent chiral resolving agents on silica gel or agarose carriers.  Since neither of these           

                carriers have been shown by the examiner to have free amido groups, it would appear that it would                        

                impossible for glutaraldehyde to function as a cross-linking agent as taught by Mikes to bond a chemically               

                modified conalbumin to the carriers as suggested by the examiner.  For these reasons, the examiner’s                     

                rejection is reversed.                                                                                                   

                                                             Other Issues                                                                

                        In the event of further prosecution of this application, the examiner should consider the following              

                issues under 35 U.S.C. § 112, second paragraph:  whether the conalbumin as defined in claim 3 has                        

                antecedent support in claim 1 and whether the chemically modified conalbumin has been properly defined                   

                in claim 4.                                                                                                              

                        1.      On pages 2 and 3 of the specification and in claim 5, appellants define the optical isomer               

                separating agent as being “conalbumin or chemically modified conalbumin.”  On page 4 of the specification,               


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