ENGVALL et al. V. DAVID et al. - Page 4




                                                      DECISION AND JUDGMENT                                                                      
                         This interference is between an application filed by Engvall et al. (Engvall) and a patent to                           
                 David et al. (David).   The real parties in interest are the respective assignees, La Jolla Cancer                              
                 Research Foundation (La Jolla) and Hybritech, Inc. (Hybritech). We award judgment against Engvall.                              
                 Therefore, Engvall is not entitled to a patent claiming the subject matter set out in claims 1 to 45 of                         
                 application  06/539,754.  David is entitled to claims 1 to 29 of patent 4,376,110.                                              
                                                              BACKGROUND                                                                         
                         The David patent issued on March 8, 1983.  The patent has resulted in at least two appeals                              
                 to the United States Court of Appeal for the Federal Circuit,  Hybritech Inc. v. Monoclonal                                     
                 Antibodies, Inc., 802 F.2d 1367, 231 USPQ 81 (Fed. Cir. 1986), cert. denied, 480 U.S. 947 (1987)                                
                 and Hybritech Inc. v. Abbott Laboratories,  849 F.2d 1446, 7 USPQ2d 1191 (Fed. Cir. 1988).                                      
                                                                   ISSUES                                                                        
                         The following issues were raised by the parties at final hearing:                                                       
                         1.       Are Engvall's claims 8 to 27 unpatentable under 35 U.S.C. § 112, ¶1, for failure to                            
                 satisfy the written description requirement?                                                                                    
                         2.       Has Engvall proved priority of invention with respect to the subject matter of the                             
                 count?                                                                                                                          
                         3.       Has Engvall proved inequitable conduct by David?                                                               
                                        THE SUBJECT MATTER OF THE INTERFERENCE                                                                   
                         The sole count in this interference provides:                                                                           
                                  In an immunometric assay to determine the presence or concentration of an                                      
                                  antigenic substance in a sample of a fluid comprising forming a ternary                                        
                                  complex of                                                                                                     
                                          a first labeled antibody,                                                                              
                                          said antigenic substance, and                                                                          
                                          a second antibody                                                                                      
                                                   said second antibody being bound to a solid carrier insoluble                                 
                                                   in said fluid                                                                                 
                                  wherein the presence of the antigenic substance in the samples is determined                                   
                                  by measuring either the amount of labeled antibody bound to the solid carrier                                  
                                  or the amount of unreacted labeled antibody,                                                                   



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