Ex parte KLOSE - Page 11




          Appeal No. 95-2441                                                          
          Application 07/987,211                                                      
          choline for use as a feed additive.  However, those products                
          were not useful in the feed of ruminants, because they                      
          decomposed in the rumen.  To solve the aforementioned problems              
          and use choline as a feed additive, Iijima teaches persons                  
          skilled in the art to coat choline or one of its derivatives                
          with a hydrophobic binder to prevent solubilization or                      
          decomposition by the rumen solution (Iijima, col. 5, l. 50-                 
          53).  The amount of choline in the granular choline                         
          composition prior to being coated with the hydrophobic binder               
          preferably is 40 to 70% by weight, more preferably 40 to 55%                
          by weight (Iijima, col. 2, l. 47-50).  Even assuming persons                
          having ordinary skill in the art would have been led by                     
          Iijima’s teaching to coat choline chloride on a cereal carrier              
          with a hydrophobic binder, an assumption inconsistent with                  
          Sibbald’s recommendation of a density of 0.8 to 2.0, persons                
          having ordinary skill in the art would have had to stretch                  
          Iijima’s teaching to find a reasonable suggestion to prepare a              
          “core comprising approximately 70% by weight of choline                     
          chloride on a cereal” (Claim 26).  Moreover, to stretch                     
          Iijima’s teaching to include about 70% choline chloride on a                
          cereal carrier appears to be inconsistent with Iijima’s                     
          preferences and would appear to serve no purpose whatsoever.                
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