Appeal No. 95-4439
Application No. 08/063,652
mercapto at the 2-position (Kim, English translation, pages 3
and 4).
(II)
The examiner next refers to Kim's trimethylsilylation
reaction, where the above-described purine compounds are
reacted with hexamethyl disilazane (HMDS) to attach a
trimethylsilyl group at the 9-position (Kim, English
translation, page 7). As pointed out by the examiner, Kim's
trimethylsilyl products differ from the compound of claim 18
because the trimethylsilyl products have hydrogen, amino, or
mercapto at the 2-position of the ring system, whereas as the
claimed compound has fluorine at the
2-position. The examiner argues that a person having ordinary
skill in the art, armed with the disclosures of Eaton and
Blumbergs, would have found it obvious to modify the
trimethylsilyl products of Kim by replacing hydrogen, amino,
or mercapto at the 2-position with fluorine. Therefore, the
-5-
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