Ex parte HIKOSAKA et al. - Page 5




               Appeal No. 96-0852                                                                                                     
               Application 08/116,581                                                                                                 


               F.2d 703, 705, 223 USPQ 1257, 1258 (Fed. Cir. 1984) ("In determining whether a case of prima                           

               facie obviousness exists, it is necessary to ascertain whether the prior art teachings would appear to be              

               sufficient to one of ordinary skill in the art to suggest making the claimed substitution or other                     

               modification.")                                                                                                        



                       In this case, Lamazou discloses a chromatography installation that addresses similar problems                  

               to those addressed by appellants, i.e., 1) heat losses in the sample tubing connecting elements of the                 

               installation and 2) the large size and complexity of prior art installations (translation, page 3). As seen            

               best in Figure 1, the installation of Lamazou includes a fixed block (13) that is made of a homogeneous                

               metallic material and which includes recesses and channels that constitute, at least in part, the means for            

               fluid introduction, the calibration means, the means for introduction of the vector or carrier fluid, the              

               detector, and the means for the actuation of at least one column (translation, pages 3-4).  The                        

               installation further includes chromatographic columns (7, 8) and a toric oven (3) which encloses the                   

               chromatographic columns and encircles the block (13).                                                                  



                       While the examiner recognizes (answer, page 4) that Lamazou fails to teach or suggest a) a                     

               heater in the valve (i.e., in block 13), b) the arrangement of the chromatographic columns in a nested                 

               manner, and c) the electronic circuitry and indicator means as set forth in the claims on appeal, we note              


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