Ex parte TWIST - Page 6




          Appeal No. 96-3824                                                           
          Application No. 08/311,635                                                   

          Nakamura because it is the next adjacent homologue of                        
          Nakamura's hydroxylamine or it would have been obvious to use                
          Wingender's diethylhydroxylamine antioxidant as an antioxidant               
          in Nakamura's composition for the purpose and advantages                     
          disclosed by Wingender.                                                      
               In the first instance, Nakamura does not disclose                       
          hydroxylamine, per se, but hydroxylamine sulfate or                          
          hydrochloride, both salts of hydroxylamine.  We also agree                   
          with appellant that the examiner has failed to factually                     
          establish a close enough structural similarity between                       
          appellant's hydroxylamines of formula (I) and the compounds of               
          Nakamura to trigger the presumption that the routineer would                 
          have been motivated to make appellants' compounds based on                   
          Nakamura's disclosure.  We agree with appellant that                         
          hydroxylamine, which contains two primary acidic hydrogen                    
          atoms in the molecule, is not an adjacent homologue of                       
          dimethylhydroxylamine or its salt.                                           
               While Wingender is admittedly directed to aqueous redox                 
          amplifier solutions which may include diethylhydroxylamine,                  
          hydrogen peroxide and a buffer, the pH's for the various                     
          compositions disclosed therein are 7.0 (column 14, lines 32                  

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