Ex parte ALFANO et al. - Page 6




          Appeal No. 97-3292                                                          
          Application 08/522,827                                                      


               The Shipp patent, for example, reveals the known practice              
          relative to the use of a trocar wherein a blade (clearly                    
          suggestive of a solid needle) is removed from the trocar in                 
          order to allow surgical instruments to pass therethrough.  We               
          are in accord with the examiner’s view that the combined                    
          teachings of Alfano and Shipp or Wilk would have clearly been               
          suggestive to one having ordinary skill in the art of                       
          inserting the probe disclosed by Alfano through a hollow tube               
          previously inserted (with a solid needle subsequently removed)              
          to obtain the expected advantage thereof.                                   




               The Janes patent makes us aware that, at the time of                   
          appellants’ invention, it was a known practice in the art to                
          follow an in-vivo optical diagnosis of tissue (system of Fig.               
          14 using a probe 268) with the removal of samples (column 2,                
          lines 34 through 36 and column 6, lines 60 through 62).  With               
          this latter knowledge, it is clear to this panel of the board               
          that one having ordinary skill in the art would have                        
          additionally found it obvious to take a sample subsequent to                
          practicing the modified Alfano procedure, supra, for the self               
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