Ex parte WONG et al. - Page 7




          Appeal No. 1996-2419                                                        
          Application No. 08/282,129                                                  


          applicants' CH R  groups attached at the 7-position of formula21                                                            
          (I) in claim 1.                                                             
               The examiner's rejection under 35 U.S.C. § 102(b) is                   
          reversed.                                                                   


                                   35 U.S.C. § 103                                    
               In setting forth the rejection of claims 1 through 4, 6,               
          8, 10, 11, and 20 through 23 under 35 U.S.C. § 103, the                     
          examiner begins with intermediate compounds 6 disclosed by                  
          Holton,                                                                     
          column 12, lines 20 through 38 where the C-7 hydroxyl group is              
          protected with triethylsilyl (see Holton, column 11, lines 60               
          through 68).  According to the examiner, Greene discloses the               
          art-recognized equivalence of triethylsilyl and various CH R2 1               
          groups attached at the 7-position of formula (I) in claim 1.                
          The examiner argues that it would have been prima facie                     
          obvious "to modify the compound of Holton by replacing the                  
          prior art triethylsilyl group with the instant - CH R  group as2 1                      
          taught by Greene et al. to form the claimed invention" because              
          the art recognized, at the time applicants' invention was                   
          made, that triethylsilyl and the aforementioned CH R  groups2 1                       

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