Ex parte CHU et al. - Page 6




          Appeal No. 1997-0204                                                        
          Application No. 08/400,786                                                  


          the separation matrix, prior to their use, so as not to impair              
          the plasma separating properties of the separation matrix.                  
          See column 6, lines 8-18.  Even if HEPES is not removed from                
          the separation matrix described in Wilk as alleged by the                   
          examiner (Answer, page 13-14), Wilk's example 2 shows at best               
          the inclusion only 10 millimolar of HEPES in the separation                 
          matrix (Wilk, column 8, lines 48-51).  Thus, we agree with                  
          appellants that the applied prior art as whole would not have               
          suggested including the claimed amount of HEPES (at least                   
          seven times more than that shown in Wilk) in the separation                 
          matrix of Chu’s assaying device.  Accordingly, on this record,              
          the examiner has not established a prima facie case of                      
          obviousness regarding the claimed subject matter within the                 
          meaning of 35 U.S.C. § 103.                                                 
               In view of the foregoing, the decision of the examiner is              
          reversed.                                                                   
               No time period for taking any subsequent action in                     
          connection with this appeal may be extended under 37 CFR                    
          § 1.136(a).                                                                 
                                   REVERSED                                           


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