Ex parte SHIRAGAMI et al. - Page 5


                  Appeal No.  1997-0481                                                                                       
                  Application No.  08/161,071                                                                                 
                         making the [cephem] compounds.  We are concerned only with the                                       
                         claimed process and the patentability thereof.  Cases such as In re                                  
                         Larsen, 292 F.2d 531, 130 USPQ 209 (CCPA 1961); In re Albertson,                                     
                         332 F.2d 379, 141 USPQ 730 (CPA 1964) and, particularly, In re                                       
                         Durden …all of which were directed to processes of making chemical                                   
                         compounds, are controlling herein… [modification original].                                          
                  Ochiai, 71 F.3d at 1568, 37 USPQ2d at 1130.                                                                 
                         However, the court stated in Ochiai, 71 F.3d at 1572, 37 USPQ2d at 1133:                             
                         [A]s we clearly indicated in In re Dillon, a recent in banc decision,                                
                         ‘[w]hen any applicant properly presents and argues suitable method                                   
                         claims, they should be examined in light of all … relevant factors, free                             
                         from any presumed controlling effect of Durden’ or any other                                         
                         precedent.  919 F.2d 688, 695, 16 USPQ2d 1897, 1903 (Fed. Cir.                                       
                         1990)(in banc), cert. denied, 500 U.S. 904 (1991).                                                   
                         In this case, the present claims are not directed to the process of reacting 2-                      
                  alkoxy-1,3-dioxolans with an acid anhydride, as taught by the reference.  Rather, the                       
                  claims are directed to a process involving uracil derivatives.                                              
                         Therefore, having compared appellants’ claims, limited as they are to the use                        
                  of a particular nonobvious starting material for making a particular nonobvious end                         
                  product, to the prior art of record, we reverse the rejection of claims 19, 20, 23, and                     
                  24 as an incorrect conclusion reached by incorrect methodology.  Compare, Ochiai,                           
                  71 F.3d at 1572, 37 USPQ2d at 1133.                                                                         
                         Having determined that the examiner has not established a prima facie case                           
                  of obviousness, we find it unnecessary to discuss the Shiragami7 reference and                              

                  corresponding unexpected results, the Ineyama Declaration executed July                                     

                                                                                                                              
                  7 Shiragami et al. (Shiragami), “Synthesis of 2’, 3’-Dideoxyuridine via                                     
                  deoxygenation of 2’,3’-O-(methoxymethylene)uridine,” J. Org. Chem., Vol. 53, pp.                            
                  5170-173 (1988).                                                                                            

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