Ex parte SHIRAHASE et al. - Page 8




              Appeal No. 1997-0838                                                                                         
              Application 08/235,238                                                                                       
                     We agree with the examiner that, based on the specification, “there could be many                     
              other issues that render the prior art unsatisfactory.”  Examiner’s Answer, page 9. In our                   
              view, appellants’ original disclosure would not convey to persons skilled in the art that                    

              “more than 50% LDH  activity” represents a limit on the range of LDH  activity for a1                                              1                                  
              clinically useful assay.  Accordingly, we find no error in the examiner’s determination that                 
              the limitation “preserving more than 50% of LDH  activity” is not supported by the                           
                                                                  1                                                        
              specification as originally filed.                                                                           
                     Rejection III of claims 10 and 11 under § 112, first paragraph, is affirmed.                          


                                                     CONCLUSION                                                            
                     We have affirmed Rejection III of claims 10 and 11 under 35 U.S.C. § 112, first                       
              paragraph, and reversed Rejection I of claims 1, 4 through 6, 10, 11, 13, 15 and 16 under                    
              35 U.S.C. § 103, as well as Rejection II of claims 10 and 11 under 35 U.S.C. § 112, first                    
              paragraph.  Thus, by our action today, claims 1, 4 through 6, 13, 15 and 16 are free of                      
              rejection.                                                                                                   












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