Ex parte ADAMS - Page 3




              Appeal No. 1997-1668                                                                                        
              Application No. 08/361,024                                                                                  


                            said components being capable of buffering said reaction to a pH of                           
                     6 - 9 and capable of promoting ligase and polymerase specificity and                                 
                     processivity.  [Emphasis added.]                                                                     

                     The references relied on by the examiner are:                                                        
              Mullis et al.  (Mullis)             4,683,195            Jul.  28, 1987                                     
              Landegren et al.  (Landegren)              4,988,617            Jan. 29, 1991                               
                     Claims 1-7 stand rejected under 35 U.S.C. § 103 as being unpatentable over                           
              Landegren in view of Mullis.  We REVERSE.                                                                   
                     In reaching our decision in this appeal we have given careful consideration to the                   
              appellant's specification and claims and to the respective positions articulated by the                     
              appellant and the examiner.  We make reference to the examiner's answer (Paper No. 37,                      
              mailed July 23, 1996) for the examiner's reasoning in support of the rejection and to the                   
              appellant's brief (Paper No. 36, filed April 22, 1996) for the appellant's arguments                        
              thereagainst.                                                                                               
                                                       OPINION                                                            

                     To establish a prima facie case of obviousness, there must be both some                              

              suggestion or motivation to modify the reference or combine reference teachings and a                       
              reasonable expectation of success.  Furthermore, the prior art must teach or suggest all                    
              the claim limitations.  In re Vaeck, 947 F.2d 488, 493, 20 USPQ2d 1438, 1442                                
              (Fed. Cir. 1991).                                                                                           


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