Ex parte RIESS et al. - Page 3




                  Appeal No. 1997-2742                                                                                                                    
                  Application 08/348,815                                                                                                                  





                                                                      35 U.S.C. § 103                                                                     

                           None of the cited references teaches or suggests that moenomycin or its                                                        
                  derivatives would be effective against H. pylori infections.   The examiner has not                                                     
                  established that a person having ordinary skill in the art would have been led from “here to                                            
                  there,” i.e., from the disclosures in Welzel, Huber, and Axon to the pharmaceutical                                                     
                  composition and method claims on appeal.                                                                                                
                           The rejection of claims 7 through 12 under 35 U.S.C. §103 as unpatentable “over                                                
                  Welzel et al. or Huber in combination with Axon” is reversed.                                                                           


                                                   35 U.S.C. §112, FIRST PARAGRAPH                                                                        

                           In their specification, appellants establish by in vitro testing that moenomycin A is                                          
                  active against H. pylori strain P22.  In further in vitro testing, appellants determine the                                             
                  minimum inhibitory concentration of moenomycin A against H. pylori strains P9, P19, and                                                 
                  M84.  See the instant specification, pages 11 and 12, Examples 1, 2, and 3.                                                             
                           On the other hand, claims 7, 8, 10 and 11 are drawn to in vivo methods for                                                     
                  controlling H. pylori infection in a patient.  Independent claim 7 recites                                                              


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