Ex parte TODARO et al. - Page 3




              Appeal No. 1997-3020                                                                                           
              Application 08/149,101                                                                                         

                      No prior art has been relied upon by the examiner in the rejection of the claims                       
              under appeal.                                                                                                  
                      Claims 1 through 28 stand rejected under 35 U.S.C. § 112, first paragraph,                             
              (enablement).  We reverse.                                                                                     
                                                   DISCUSSION                                                                
              1. Claims 1 through 11 and 27                                                                                  
                      The patent examiner bears the initial burden of providing reasons why a supporting                     
              disclosure does not enable one skilled in the art to make and use a claimed invention.  In                     
              re Marzocchi, 439 F.2d 220, 223, 169 USPQ 367, 369 (CCPA 1971).  The examiner’s                                
              position concerning the enablement of the appealed claims is two-fold.  First, the examiner                    
              is of the opinion that it would require undue experimentation for one skilled in the art to                    
              make the hybrid cytokines such that the hybrid cytokines possess a desired activity.                           
              Second, the examiner is of the opinion that there is an unpredictability in the activity of any                
              one hybrid cytokine encompassed by the claims on appeal.                                                       
                      It is noted that the examiner has stated on the record that the specification is                       
              enabling for hybrid cytokines having the conformation LLLI, LLLI", IIIL, IIIL", IIIG and IGGI                  
              since specific examples are set forth in the specification concerning the manufacture and                      
              use of these hybrid cytokines.  However, the examiner is of the opinion that the                               
              specification does not reasonably provide enablement for all of the hybrid cytokines                           
              encompassed by claim 1.                                                                                        

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