Ex parte GRANADOS - Page 10


                       Appeal No. 1997-3116                                                                                                                      
                       Application 08/294,953                                                                                                                    

                       secreted alkaline phosphatase gene, under specific culture conditions.2  The                                                              
                       instant specification provides evidence that the Tn-5B1-4 cell line meets this                                                            
                       limitation.  See pages 12-13 and Table 3 (showing alkaline phosphatase                                                                    
                       expression at an average of 2.29 IU/ml in cell line Tn-5B1-4).                                                                            
                                                                         Summary                                                                                 
                                 We reverse the rejection of claims 1-8 and affirm the rejection of claims 9                                                     
                       and 10.  We also enter a new ground of rejection of claims 1 -3, 7, and 8, based                                                          
                       on anticipation.  As a result, claims 4-6 are free of rejection.                                                                          


                                 In addition to affirming the examiner=s rejection of one or more claims, this                                                   
                       decision contains a new ground of rejection pursuant to 37 CFR ' 1.196(b)                                                                 
                       (amended effective Dec. 1, 1997, by final rule notice, 62 Fed. Reg. 53,131,                                                               
                       53,197 (Oct. 10, 1997), 1203 Off. Gaz. Pat. & Trademark Office 63, 122                                                                    
                       (Oct. 21, 1997)).  37 CFR ' 1.196(b) provides, AA new ground of rejection shall                                                           
                       not be considered final for purposes of judicial review.@                                                                                 
                                                             TIME PERIOD FOR RESPONSE                                                                            
                                 Regarding any affirmed rejection, 37 CFR ' 1.197(b) provides:                                                                   
                                 (b) Appellant may file a single request for rehearing within two                                                                
                                 months from the date of the original decision . . . .                                                                           



                                                                                                                                                                 
                       infection by a recombinant . . . virus expressing secreted alkaline phosphatase.”  The claim                                              
                       obviously should recite a recombinant virus expressing ß-galactosidase.                                                                   
                       2 Claim 8 also contains an apparent typographical error that should be corrected if this case is                                          
                       subject to further examination.  Claim 8  is drawn to cells expressing a specific level of alkaline                                       
                       phosphatase but recites measuring, in step (i), “ß-galactosidase production at six days post                                              
                       infection.”  The enzyme measured should obviously be alkaline phosphatase.                                                                

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