Ex parte HENICK-KLING et al. - Page 6




                 Appeal no. 1997-3953                                                                                                               
                 Application 08/392,615                                                                                                             
                 claimed composition that would distinguish it from the prior art composition (which is                                             
                 clearly capable of supporting the growth of malolactic bacteria).  In re Pearson, 494 F.2d                                         
                 1399, 1403, 181 USPQ 641, 644 (CCPA 1974).  Similarly, the examiner’s rationale for                                                
                 modifying Henick-Kling’s medium relies on one of ordinary skill in the art having some                                             
                 reason to convert the prior art medium to a “starter medium,” but no reason is given.                                              
                 Moreover, there is uncontroverted evidence of record that the ratio of fructose to glucose                                         
                 does not increase during the ripening of grapes.  See the declaration of Dr. Henick-Kling,                                         
                 submitted December 14, 1995.                                                                                                       
                          In our view, the only difference between Henick-Kling’s MRSM and the claimed                                              
                 medium is the ratio of glucose to fructose, and/or the overall concentration of glucose plus                                       
                 fructose; and the dispositive issue is simply whether there is any reason, stemming from                                           
                 the prior art, to modify the carbohydrate content of Henick-Kling’s MRSM in the manner                                             
                 required by the present claims.                                                                                                    
                          Turning to the Examiner’s Answer (pages 4 and 5), under the heading “Response to                                          
                 Argument,” we find the following statement from the examiner:                                                                      
                          It has been clearly established in the prosecution of this case that the prior                                            
                          art discloses that the various proportions and amounts of the ingredients                                                 
                          used in the claimed composition, i.e. fructose/glucose and malic acid, are                                                
                          result effective variables which be [sic] routinely optimized by one of ordinary                                          
                          skill in the art in practicing the invention disclosed by that reference . . . [i]t is                                    
                          well within the purview of the skilled artisan to vary fermentation conditions                                            
                          via routine experimentation in order to optimize microbial growth or                                                      
                          production.                                                                                                               



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