Appeal No. 1997-2319
Application No. 08/147,707
Claims 1, 5, 6, 10 and 11 are illustrative of the subject matter on appeal and read
as follows:
1. A method for identifying one or more populations of human progenitor cells,
said populations comprising lymphoid, erythroid and myeloid progenitors, comprising
the steps of labeling a sample of human cells containing said populations with a marker
for CD34, a marker for CD38 and one or more markers for cell adhesion molecules
and/or growth factor receptors and identifying said populations based upon the
expression of each of the markers.
5. The method of claim 1 wherein said growth factor receptors are selected from
the group consisting of SCFR, GM-CSFR, IL-6R, gp130/IL-6R and IL-7R.
6. A method for isolating one or more populations of human progenitor cells,
said populations comprising lymphoid, erythroid and myeloid progenitors, comprising
the steps of labeling a sample of human cells containing said populations with a marker
for CD34, a marker for CD38 and one or more markers for cell adhesion molecules
and/or growth factor receptors and isolating said populations based upon the
expression of each of the markers.
10. The method of claim 6 wherein said growth factor receptors are selected
from the group consisting of SCFR, GM-CSFR, IL-6R, gp130/IL-6R and IL-7R.
11. An isolated population of human progenitor cells prepared according to the
method of claim 6.
The references relied on by the examiner are:
Terstappen et al. (Terstappen), “Sequential Generations of Hematopoietic Colonies
Derived from Single Nonlineage-Committed CD34+ CD38- Progenitor Cells, “ Blood, Vol.
77, pp. 1218-1227, 1991
Armitage et al. (Armitage), “Identification of a Novel Low-Affinity Receptor for Human
Interleukin-7,” Blood, Vol. 79, pp. 1738-1745, 1992
McClanahan et al. (McClanahan), “Hematopoietic Growth Factor Receptor Genes as
Markers of Lineage Commitment during In Vitro Development of Hematopoietic Cells,”
Blood, Vol. 81, pp. 2903-2915, 1993
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