Appeal No. 1997-2509
Application No. 08/230,982
Claims 1 and 8 are illustrative of the claims on appeal and read as follows:
1. A composition comprising IL-11 and glycine.
8. A composition comprising IL-11, glycine, and a buffering agent.
The prior art references relied upon by the examiner are:
Kwan 4,496,537 Jan. 29, 1985
Kato et al. (Kato) 4,675,183 Jun. 23, 1987
Singh et al. (Singh) 5,215,743 Jun. 1, 1993
Patel 5,358,708 Oct. 25, 1994
Wang et al. (Wang), “Parenteral formulation of proteins and peptides: Stability and
stabilizers,” J. Parenteral Sci. Tech., Vol. 42(S), No. 2S, pp. S3-S26 (1988)
Manning et al. (Manning), “Stability of protein pharmaceuticals,” Pharm. Res., Vol. 6, No.
11, pp. 903-918 (1989)
Paul et al. (Paul), “Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-
derived lymphopoietic and hematopoietic cytokine,” Proc. Natl. Acad. Sci., Vol. 87, pp.
7512-7516 (1990)
A reference relied upon by the appellant is:
Minasian et al. (Minasian), “A review of cytokine structures,” Protein Seq Data Anal,
Vol. 5, pp. 57-64 (1992)
Grounds of Rejection
Claims 1-20 stand rejected under 35 U.S.C. § 103 as obvious over Wang and
Manning in view of Paul taken with Kwan, Kato, Singh and Patel.
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