Ex parte DEROSCH et al. - Page 6




                  Appeal No. 1997-2743                                                                                                                    
                  Application No. 08/442,252                                                                                                              
                  select the elements from the cited prior art references for combination in the manner                                                   
                  claimed.’”  Ecolochem Inc. v. Southern California Edison, 227 F.3d 1361, 1375, 56                                                       
                  USPQ2d 1065, 1075-76 (Fed. Cir. 2000).                                                                                                  
                           In our judgment, the only reason or suggestion to modify the teachings of the                                                  
                  references in the manner proposed by the examiner comes from appellants’ specification.                                                 
                  Accordingly, on this record, we find that the examiner’s burden of establishing a prima                                                 
                  facie case of obviousness has not been met and the rejection of claims 1, 3 through 8 and                                               
                  15 through 18 is reversed.                                                                                                              
                  Rejection II                                                                                                                            
                           Pitha teaches that both unmodified and modifed cyclodextrins (for example,                                                     
                  hydroxypropyl cyclodextrin) are used to stabilize pharmaceutical compositions, but does                                                 
                  nothing to remedy the underlying deficiency in the examiner’s proposed combination of                                                   
                  Feld, Deutsch and Woulfe.                                                                                                               
                           Accordingly, the rejection of claims 9 through 12 as unpatentable over Feld,                                                   
                  Deutsch, Woulfe and Pitha is reversed as well.                                                                                          
                                                                    REVERSED                                                                              


                                                                                                   )                                                      
                                                      Sherman D. Winters                           )                                                      
                                                      Administrative Patent Judge                  )                                                      
                                                                                                   )                                                      
                                                                                                   )                                                      
                                                                                                   ) BOARD OF PATENT                                      

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