Ex parte GAULER et al. - Page 3


                 Appeal No.  1997-2744                                                                                 
                 Application No.  08/243,520                                                                           
                 THE REJECTION UNDER 35 U.S.C. § 103:                                                                  
                        Initially, we note the examiner’s statement of the rejection (Answer, ¶ 11)                    
                 “[c]laims 15-23 are rejected under 35 USC 103.  This rejection is set forth in the                    
                 prior Office action of September 20, 1994 paper number 18.”  This statement                           
                 appears to be in error.  Paper number 18 refers to a rejection of claims 1-12, not                    
                 claims 15-23.  In fact this record never contained 23 claims.  Furthermore, while                     
                 both the examiner’s Answer (¶ 13) and appellants’ Brief refer to the combination of                   
                 Isgaard and Mueller, Paper No. 18 sets forth a single rejection under            35                   
                 U.S.C. § 103 over Isgaard.  Therefore, since the most recent Final Rejection5 of the                  

                 claims is more consistent with the arguments of the examiner and appellants we                        
                 believe the examiner intended to refer to this paper for the basis of the rejection.                  
                 With this clarification, we proceed to address the merits of the examiner’s rejection.                
                        The initial burden of presenting a prima facie case of obviousness rests on                    
                 the examiner.  In re Oetiker, 977 F.2d 1443, 1445, 24 USPQ2d 1443, 1444 (Fed.                         
                 Cir. 1992).  In satisfying this initial burden, “[i]t is impermissible within the framework           
                 of section 103 to pick and choose from any one reference only so much of it as will                   
                 support a given position to the exclusion of other parts necessary to the full                        
                 appreciation of what such reference fairly suggests to one of ordinary skill in the art.”             
                 In re Wesslau, 353 F.2d 238, 241, 147 USPQ 391, 393 (CCPA 1965); see also In                          
                 re Mercier, 515 F.2d 1161, 1165-66, 185 USPQ 774, 778 (CCPA 1975).                                    
                        The examiner finds (Answer, bridging paragraph, pages 3-4) that “Mueller                       
                 teaches that appellants’ active [sic] used to treat experimental rats [sic] used to                   



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