Ex Parte VAN ASSCHE et al - Page 5


                Appeal No. 1997-4272                                                                          
                Application No. 08/429,053                                                                    

                speculation and assumptions is legal error.).  Therefore, we vacate the rejection             
                of claim 23 under 35 U.S.C. § 103.                                                            
                2.    Claim 11                                                                                
                      The examiner rejected claim 11 as obvious over the combined teachings                   
                of Walker and Kalt-Torres.  The examiner argues that those skilled in the art                 
                would have been led to combine the partially purified maize SPS enzyme of Kalt-               
                Torres with the hybridoma-producing process of Walker with a reasonable                       
                expectation of obtaining hybridomas that secrete monoclonal antibodies specific               
                for maize SPS.  Examiner’s Answer, pages 6-7.  The examiner does not allege                   
                that either reference discloses the specific hybridomas recited in the claim but              
                argues that the claimed cell lines                                                            
                      are obvious since the record does not contain any evidence that the                     
                      cell lines differ in any significant manner or produce monoclonal                       
                      antibodies that differ in any significant aspect from hybrid[oma] cell                  
                      lines that one of ordinary skill in the art would expect to generate                    
                      using an extract of maize as the starting antigen (Kalt-Torres et al.)                  
                      in the basic method of Walker.                                                          
                Id., page 8.                                                                                  
                      The examiner is correct that if the products made obvious by the prior art              
                reasonably appear to be the same as those claimed, Appellants bear the burden                 
                of showing that they are not.  See In re Spada, 911 F.2d 705, 708, 15 USPQ2d                  
                1655, 1658 (Fed. Cir. 1990) (“[W]hen the PTO shows sound basis for believing                  
                that the products of the applicant and the prior art are the same, the applicant              
                has the burden of showing that they are not.”).  In this case, however, the                   
                examiner’s attempt to shift the burden of proof to Appellants was premature.                  


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