Ex parte HEIMBURGER et al. - Page 8



                    Appeal No. 1999-0959                                                                                               
                    Application No. 08/415,166                                                                                         

                    section 103, teachings of references can be combined only if there is some suggestion                              
                    or incentive to do so.’  Although couched in terms of combining teachings found in the                             
                    prior art, the same inquiry must be carried out in the context of a purported obvious                              
                    ‘modification’ of the prior art.”  Id. at 1266, 23 USPQ2d at 1783 (citations omitted,                              
                    emphasis in original).                                                                                             
                           The examiner asserts that those skilled in the art would have found it                                      
                    obvious in view of the Schwinn patents to practice the claimed method employing                                    
                    calcium ions at 1 -30 mM and a chelating agent at 1-7 mM.  However, the prior art                                  
                    teaches use of these reagents at concentrations significantly higher than those                                    
                    recited in the claims, i.e., calcium at 50-2000 mM and chelating agent at 10-300                                   
                    mM.  The examiner points to nothing in the references that would have led a                                        
                    person of ordinary skill in the art to modify the disclosed methods by using                                       
                    calcium and chelating agent at the concentrations recited in the claims.  Nor does                                 
                    the  examiner provide other evidence or reasoning that would have led those                                        
                    skilled in the art to modify the method disclosed by the Schwinn patents by                                        
                    reducing the concentrations of calcium and chelating agent.                                                        
                           “The mere fact that the prior art may be modified in the manner suggested                                   
                    by the Examiner does not make the modification obvious unless the prior art                                        
                    suggested the desirability of the modification.”  In re Fritch, 972 F.2d at 1266, 23                               
                    USPQ2d at 1783.  Since the relied-on references do not provide motivation to                                       
                    modify a known process as required by the claims, they do not support a prima                                      
                    facie case of obviousness.  The rejection is reversed.                                                             


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