Appeal No. 1999-1245
Application No. 08/245,282
Claim 46 is illustrative of the claims on appeal and reads as follow:
46. A method for modulating a response by a T cell expressing a CD28 cell
surface receptor which binds a costimulatory molecule, comprising contacting the T cell
with an agent which acts intracellularly to modulate production of D-3 phosphoinositides
in the T cell.
The prior art references relied upon by the examiner are:
Ward et al. (Ward 1993), ?Ligation of CD28 receptor by B7 induces formation of D-3
phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation,”
European J. of Immunology, Vol. 23, pp. 2572-2577 (1993)
Vandenberghe et al. (Vandenberghe), ?Antibody and B7/BB1-mediated Ligation of the
CD28 Receptor Induces Tyrosine Phosphorylation in Human T Cells,” The Journal of
Experimental Medicine, Vol. 175, pp. 951-960 (1992)
Ward et al. (Ward 1992), ?Regulation of D-3 Phophoinositides during T Cell activation
via the T cell antigen receptor/CD3 complex and CD2 antigens,” European Journal of
Immunology, Vol. 22, pp. 45-49 (1992)
Okada et al (Okada), ?Essential Role of Phosphatidylinositol 3-Kinase in Insulin-
Induced Glucose Transport and Antilipolisis in Rat Adipocytes,” The Journal of
Biological Chemistry, Vol. 269, No. 5, pp. 3568-3573 (1994)
Reference relied on by appellant:
Sato et al. (Sato), ?Effects of Wortmannin Analogs on Bone in Vitro and in Vivo,” The
Journal of Pharmacology and Experimental Therapeutics, Vol. 277, pp. 543-550 (1996)
References cited by the Merits Panel:
Bonjouklian et al (Bonjouklian 1) 5,378,725 Jan. 3, 1995
(Filed Jul. 19, 1993)
Bonjouklian et al (Bonjouklian 2) 5,507,103 April 2, 1996
(Filed Aug. 25, 1993)
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