Ex parte SILVERMAN et al. - Page 6




              Appeal No. 1999-1437                                                                                     
              Application No. 08/732,065                                                                               

              isomer from the racemic mixture described by Handa.  Further, the examiner has offered                   
              nothing which would establish that the reference is enabling for a process which would                   
              yield the isolated S-isomer in question.  See  In re Hoeksema, 399 F. 2d 269, 273, 158                   
              USPQ 596, 600 (CCPA 1968).  Thus, the examiner has fail to establish that one of                         
              ordinary skill would have been led to modify the explicit teaching of the reference in a                 
              manner to arrive at the claimed invention since the prior art does not suggest the                       
              desirability of the modification.  In re Gordon, 733 F.2d 900, 902, 221 USPQ 1125, 1127                  
              (Fed. Cir. 1984).  In re Fritch, 972 F.2d 1260, 1266, n.14, 23 USPQ2d 1780, 1783-84,                     
              n.14 (Fed. Cir. 1982).  In the absence of such evidence, the only suggestion to isolate the              
              (S)-isomer for use in appellants' process is provided by appellants’ disclosure of the                   
              invention.  However, use of this information as a basis for establishing a prima facie case              
              of obviousness, within the meaning of 35 U.S.C. § 103, would constitute impermissible                    
              hindsight.  There must be some reason, suggestion, or  motivation found in the prior art                 
              whereby a person of ordinary skill in the field of the invention would make the modifications            
              required.  That knowledge can not come from the applicant’s invention itself.   Diversitech              
              Corp. v. Century Steps, Inc.,  850 F.2d 675, 678-79,  7 USPQ2d 1315, 1318 (Fed. Cir.                     
              1988); In re Geiger, 815 F.2d 686, 688, 2 USPQ2d 1276, 1278 (Fed. Cir. 1987);                            
              Interconnect Planning Corp. v. Feil, 774 F.2d 1132, 1143,  227 USPQ 543, 551 (Fed. Cir.                  
              1985).  Thus, on this record, the examiner has not provided those facts or evidence which                
              would reasonably support a conclusion that the claimed subject matter would have been                    
              prima facie obvious within the meaning of 35 U.S.C. § 103.  Where the examiner fails to                  


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