Appeal No. 1999-2230
Application 08/465,236
22. Microcapsules, suitable for intra-arterial administration, being hollow and
enclosing a gas- or vapor-filled space essentially without solid material therein and being
capable of being dried to form a powder of such microcapsules, in which more than 30%
of the microcapsules have a diameter within a 2 :m range and at least 90% have a
diameter within the ranges 12.0-25.0 :m. [Emphasis added.]
23. Microcapsules, suitable for intra-arterial administration, being hollow and
enclosing a gas- or vapor-filled space essentially without solid material therein and being
capable of being dried to form a powder of such mircocapsules, in which the interquartile
range of diameters is 2 :m or less and the median diameter is between 12.0 :m and 25.0
:m inclusive. [Emphasis added.]
24. A pharmaceutical composition suitable for intra-arterial administration,
comprising hollow microcapsules of which at least 90% have a diameter of 12.0-25.0 :m,
and at least 30% have a diameter within a 2 :m range essentially without solid material
therein and being capable of being dried to form a powder of such microcapsules.
[Emphasis added.]
28. A process comprising the step of atomizing a solution or dispersion of a wall-
forming material in a liquid carrier into a gas in order to obtain hollow microcapsules by
evaporation of the liquid carrier, wherein said microcapsules are suitable for intra-arterial
administration, at least 90% of the microcapsules are 12.0-25.0 :m in diameter, and at
least 30% have a diameter within a 2 :m range. [Emphasis added.]
The References
In rejecting the appealed claims on prior art grounds, the examiner relies on the
following references:
Sands 4,420,442 Dec. 13, 1983
Erbel et al. (Erbel) 5,137,928 Aug. 11, 1992
Mathiowitz et al. (Mathiowitz) 5,271,961 Dec. 21, 1993
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