Ex Parte SAMARITANI et al - Page 19



            solution of r-hCG and mannitol would infringe applicants' claim                              
            1.  For a variety of reasons, many of which are apparent from our                            
            findings, we are not prepared to say that applicants'                                        
            specification evidences unexpected results.  However, assuming                               
            arguendo it does, then what surfaces in this appeal that                                     
            applicants' claim is too broad in the sense of 35 U.S.C. § 103.                              
            In re Muchmore, 433 F.2d 824, 826, 167 USPQ 681, 683 (CCPA 1970)                             
            (claims which include obvious subject matter and non-obvious                                 
            subject matter are not patentable under § 103).  A claim which                               
            would preclude the public from using an injection solution                                   
            reconstituted from lyophilized r-hCG and mannitol runs afoul of                              
            § 103.                                                                                       
                                                   c.                                                    
                  Since our rationale in support of obvious is not that of the                           
            examiner, it would be fair to say that applicants have not had a                             
            reasonable opportunity to anticipate our rationale and address                               
            it.  We nevertheless feel it appropriate to address some of                                  
            applicants' arguments.                                                                       
                  According to applicants (Appeal Brief, page 3), it has been                            
            established that the stability of lyophilized hCG compositions                               
            containing sucrose "is better" than similar compositions                                     
            stabilized with other materials, such as lactose or mannitol.                                
            Accordingly, applicants make an argument in the form of a                                    
            question to the effect: "Why in the world would one skilled in                               
            the art even 'try' to use mannitol in place of sucrose?"  While                              

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