Ex parte PRASAD et al. - Page 8


                  Appeal No. 2001-0849                                                           Page 8                    
                  Application No. 08/990,120                                                                               

                  suggested to one of ordinary skill to conduct the claimed invention at a pH within the                   
                  claimed ranges.  Examiner never provides an explanation and it is not satisfied by                       
                  making statements that the claimed pH limitation is “not in and of itself patentable”                    
                  or inherently covered by the term “dilute acid.”  Until such an explanation is given, we                 
                  are not in a position to review the appropriateness of the rejection.                                    
                         Accordingly, examiner needs to clarify the grounds for establishing a prima                       
                  facie case of obviousness for combining the prior art disclosures.                                       
                         Finally, another difficulty arises as a result of the examiner never fully                        
                  addressing the experimental data set forth in appellants’ Declaration of November                        
                  16, 1999 (paper no. 12).  According to appellants’ Brief (bottom p. 4), the                              
                  “Declaration previously filed by Appellants on November 12, 1999, demonstrates                           
                  the criticality of pH on the net yield of the TDA sulfoxide.” Appellants go on to                        
                  discuss the results set forth on the Declaration.  We do not know examiner’s                             
                  position regarding the data. This is all that we could find on the subject (Examiner’s                   
                  Answer, p. 5):                                                                                           
                         Applicant’s amendment filed 3/1/99 and the arguments together with a                              
                     declaration filed 11/2/99 have been fully considered but they are not persuasive.                     
                     Applicants amended claims 1, 5-6, 10 and 14-15, wherein the pH of the claimed                         
                     oxidation process is limited to ‘about 0.5 to about 5.0’. In the argument filed                       
                     11/2/99 applicants refer to the accompanying declaration for support that the pH                      
                     range of about 0.5 to 5.0 is very critical to the instantly claimed process (as the                   
                     pH increases from 5.5 to 0.5, percent yield decreases).  … Applicants also                            
                     contend that [Shanklin] do not suggest the criticality of controlling the pH of the                   
                     reaction. This is not persuasive because the process of [Shanklin] (column 6,                         
                     reaction Iva-2) was performed in dilute acid solution and as such, the pH of the                      
                     reaction solution must be within the range of 0.5 to 5.0.                                             








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