Ex Parte CARROLL - Page 4


                 Appeal No.  2001-1298                                                          Page 4                  
                 Application No.  08/304,602                                                                            
                               limitation, thus giving no instruction of it or of the particular                        
                               cross[-]linking conditions necessary to provide the claimed                              
                               conjugates to one of ordinary skill in the art.                                          
                                      Because of the absence of any of this information                                 
                               from Drabick, as well as absence of even a suggestion of                                 
                               using crosslinking chemistry, it is improper to combine                                  
                               Drabick with any other art.  Since the reference cannot be                               
                               properly combined, there is no prima facie showing of                                    
                               obviousness.                                                                             
                 We agree with appellant.                                                                               
                        As set forth in In re Kotzab, 217 F.3d 1365, 1369-70, 55 USPQ2d                                 
                 1313, 1316 (Fed. Cir. 2000):                                                                           
                        A critical step in analyzing the patentability of claims pursuant to                            
                        section 103(a) is casting the mind back to the time of invention, to                            
                        consider the thinking of one of ordinary skill in the art, guided only                          
                        by the prior art references and the then-accepted wisdom in the                                 
                        field. … Close adherence to this methodology is especially                                      
                        important in cases where the very ease with which the invention                                 
                        can be understood may prompt one “to fall victim to the insidious                               
                        effect of a hindsight syndrome wherein that which only the                                      
                        invention taught is used against its teacher.”                                                  
                                                          …                                                             
                        Most if not all inventions arise from a combination of old elements.                            
                        … Thus, every element of a claimed invention may often be found                                 
                        in the prior art. … However, identification in the prior art of each                            
                        individual part claimed is insufficient to defeat patentability of the                          
                        whole claimed invention. … Rather, to establish obviousness based                               
                        on a combination of the elements disclosed in the prior art, there                              
                        must be some motivation, suggestion or teaching of the desirability                             
                        of making the specific combination that was made by the applicant.                              
                        [citations omitted]                                                                             




                        In other words, “there still must be evidence that ‘a skilled artisan, ... with                 
                 no knowledge of the claimed invention, would select the elements from the cited                        
                 prior art references for combination in the manner claimed.’” Ecolochem Inc. v.                        







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