Appeal No. 2001-1654 Page 2
Application No. 08/445,584
d. A substance which inhibits the binding of immunoglobulin G
to the solid phase and which inhibits the binding of said labeled
antigen to immunoglobulin G.
17. An immunological method for the detection of an antigen specific
antibody comprising one or more of the immunoglobulin classes A, M, D,
or E in a fluid, comprising the simultaneous incubation of:
a. A solid phase having bonded thereto antibody specific for said
immunoglobulin classes A, M, D, or E;
b. A fluid containing an immunoglobulin of class A, M, D, or E;
c. An unlabeled antigen immunologically reactive to the fluid phase
immunoglobulin;
d. A labeled antibody, immunologically reactive with said unlabeled
antigen; and
e. A substance which inhibits the binding of immunoglobulin G to
the solid phase and which inhibits the binding of said unlabeled
antigen to immunoglobulin G.
8. The method as claimed in claim 16, wherein the labeling means are
erythrocytes.
The examiner relies on the following references:
Molinaro et al. (Molinaro) 4,130,634 Dec. 19, 1978
Duermeyer 4,292,403 Sept. 29, 1981
Unger 4,434,227 Feb. 28, 1984
David et al. (David) 4,486,530 Dec. 04, 1984
Schmitz et al. (Schmitz), “Detection of IgM Antibodies to Cytomegalovirus (CMV)
Using an Enzyme-labelled Antigen (ELA)”, Journal of General Virology, Vol. 50
pp. 59-68 (1980)
Claims 4-7, 13, 14, 16-21, 23, and 24 stand rejected under 35 U.S.C.
§ 103 as obvious in view of Duermeyer, Unger, David, and Schmitz.
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