Ex Parte PILLAI et al - Page 6


                     Appeal No. 2001-1779                                                                                                           
                     Application No. 09/398,898                                                                                                     


                              US ‘926 teaches an organic extract of chickpea.  US ‘926 further                                                      
                              teaches at column 8, lines 35 to 38 that the quantity of active                                                       
                              material is that which will produce the desired therapeutic effect.                                                   
                              There is no data or evidence of record that the chickpea extracts of                                                  
                              US ‘926 do not provide the amount of estrogenic activity as                                                           
                              instantly claimed.                                                                                                    
                              We note, as pointed out by the examiner, that US ‘926 discloses at                                                    
                     column 1, lines 50-59 that “Cicer arietinum” (chickpea) can be extracted in                                                    
                     hexane, methanol, or acetone as an initial step in obtaining the steryl-β-D-                                                   
                     glucosides which are the ultimate object of the extraction procedure disclosed by                                              
                     US ‘926.  However, the examiner does not point to any facts or evidence which                                                  
                     establish that such an extract will necessarily have an estrogenic activity                                                    
                     equivalent to the claimed concentration of estradiol.  Like WO ‘069, US ‘926 does                                              
                     not disclose any examples wherein an organic extract of chickpea is actually                                                   
                     prepared.  US ‘926 therefore does not provide factual evidence, such as starting                                               
                     amounts of chickpea or chickpea extract, or amounts of extraction solvent, which                                               
                     establish that any chickpea extract disclosed by US ‘926 will necessarily have the                                             
                     claimed estrogenic activity.                                                                                                   
                              We note further, as pointed out by the examiner, that US ‘926 discloses at                                            
                     column 8, lines 35-38 that the quantity of active material is the amount calculated                                            
                     to produce a therapeutic effect.  However, the active ingredients of US ‘926 are                                               
                     “steryl-β-D-glucosides” having hemostatic, vascular stabilizing and antishock                                                  
                     therapeutic activities.  US ‘926 at column 1, lines 12-56.  Thus, even if US ‘926 is                                           
                     considered to disclose organic chickpea extracts having therapeutic properties, it                                             
                     is not clear that a therapeutic extract prepared according to US ‘926 will                                                     

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