Ex Parte YOULE et al - Page 11

                 Appeal No.  2001-0733                                                      Page 11                    
                 Application No. 09/095,429                                                                            

                 rejection therefore sets forth no teaching, suggestion, or motivation, of why the                     
                 ordinary artisan would have chosen to mutate the methionine at position 23, add                       
                 the methionine start codon at position -1, and cleave the protein using                               
                 cyanogens bromide, over other ways of recombinantly expressing the protein,                           
                 such as that taught by Louis, as each requires a change to the sequence of the                        
                 native protein.                                                                                       


                                                     REVERSED                                                          




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                 LG/dym                                                                                                








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