Appeal No. 2002-0795
Application No. 09/128,036
a scaffold compound that comprises at least one reactive
functionality, contacting the scaffold compound with a mixture
that comprises at least four appendage moieties to form covalent
bonds with the reactive functionalities on the scaffold to form
an intermediate library, and reacting the intermediate library
compounds with a reducing agent to reduce the covalently bound
appendage moieties, thereby forming the desired library of
chemical compounds (Brief, pages 2-3).
Illustrative independent claim 1 is reproduced below:
1. A method of preparing a library of chemical compounds
comprising:
providing a scaffold comprising at least one reactive
functionality thereon; contacting said scaffold with a mixture
comprising at least four appendage moieties to form covalent
bonds between said at least four appendage moieties and said at
least one reactive functionality, thereby forming an intermediate
library; and contacting said intermediate library with a reducing
agent under conditions effective to reduce said covalently bound
appendage moieties, thereby forming said library of chemical
compounds.
The examiner relies upon the following references as
evidence of obviousness:
Cody et al. (Cody) 5,324,483 Jun. 28, 1994
Smith et al. (Smith), “Synthesis and Biological Evaluation of a
Library containing potentially 1600 Amides/Esters. A Strategy
for Rapid Compound Generation and Screening,” 2821-2824
Bioorganic & Medicinal Chemistry Letters, Vol. 4, No. 24, Dec.
22, 1994.
2
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