Ex Parte Albers et al - Page 2


                 Appeal No. 2003-0839                                                          Page 2                    
                 Application No. 09/646,339                                                                              

                        Claim 1 is representative of the appealed claims and reads as follows:                           
                        1.      Moulded items made form a thermoplastically processable                                  
                                polyurethane containing a homogeneous distribution of an antibiotic                      
                                substance which have a peak-to-valley surface roughness of                               
                                <5 µm.                                                                                   
                        The examiner relies on the following references:                                                 
                 Darouiche et al. (Darouiche)               5,624,704            Apr. 29, 1997                           
                 Solomon et al. (Solomon)                   5,707,366            Jan. 13, 1998                           
                        Claims 1, 3, and 4 stand rejected under 35 U.S.C. § 103 as obvious in                            
                 view of Solomon.                                                                                        
                        Claim 8 stands rejected under 35 U.S.C. § 103 as obvious in view of                              
                 Solomon and Darouiche.                                                                                  
                        We reverse.                                                                                      
                                                      Background                                                         
                        The specification discloses that the use of polymeric materials in medicine                      
                 “has led to a dramatic increase in so-called foreign body infections / polymer                          
                 associated infections.”  Page 1.  For example, “central venous catheters are                            
                 responsible for about 90% of all cases of sepsis in intensive medicine.”  Page 2.                       
                 Attempts have been made to decrease infections associated with polymeric                                
                 medical articles by incorporating antimicrobial compounds into them, either at the                      
                 surface or within the polymer matrix.  See pages 2-3.                                                   
                        The specification discloses “moulded items made from thermoplastic                               
                 polyurethanes which contain a homogeneous distribution of an antibiotic                                 
                 substance and which have a peak-to-valley surface roughness of <5 µm.”                                  







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