Ex Parte HOLLIS et al - Page 3


                 Appeal No. 2003-0847                                                      Page 3                   
                 Application No. 08/744,685                                                                         

                 obvious by the combination of Fell A or Fell B as combined with Yamawaki-                          
                 Kataoka.  After careful review of the record and consideration of the issues                       
                 before us, we reverse all of the rejections of record.  Note that in deciding this                 
                 appeal, we have also considered the issues in related Appeal No. 2003-1594,                        
                 Application No. 08/970,266.                                                                        
                                                  DISCUSSION                                                        
                 1.    Rejection under 35 U.S.C. § 112, first paragraph (New Matter)                                
                       Claims 19, 23 and 27 stand rejected under 35 U.S.C. § 112, first                             
                 paragraph, as containing subject matter that was not described in the                              
                 specification in such a way as to reasonably convey to one skilled in the relevant                 
                 art that the inventors, at the time of filing, had possession of the claimed                       
                 invention.                                                                                         
                       As an initial matter, we note that the Examiner’s Answer references two                      
                 prior office actions in which the rejection is set forth, Paper Nos. 17 and 24.  An                
                 Examiner’s Answer should not, however, reference more than a single prior                          
                 office action.  See  MPEP 1208 (“An examiner’s answer should not refer, either                     
                 directly or indirectly, to more than one prior Office action.”).  Moreover, where                  
                 there is confusion of what constitutes the rejection, as there is in this case, the                
                 examiner’s answer should set forth the rejection in its entirety in the answer                     
                 rather than referencing the prior actions.                                                         
                       To the best of our understanding, the examiner is objecting to the                           
                 reference to the selectable markers xanthene-guanine                                               
                 phosphoribosyltransferase (gpt) and dihydrofolate reductase (dhfr).  The                           





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