Ex Parte MURLEY et al - Page 2



              Appeal No. 2003-0934                                                                     Page 2                 
              Application No. 08/769,596                                                                                      
              Andermann and Cornell.  The examiner’s Answer refers to paper no. 13 for the                                    
              statement of the rejection.  We reverse the examiner’s rejection of the claims.                                 
                                                       DISCUSSION                                                             
                      Claim 8 is directed to a therapeutic wound gel consisting essentially of, by weight                     
              percentage, about 88-97% water, about 0.4-0.6% carbomer, about 1.2-7.8% propylene                               
              glycol, about 0.6-1.3% glycerin, about 0.5% DMDM Hydantoin, and about 0.1% of a                                 
              chondroitin sulfate and animal protein.  According to the specification (page 2), “about                        
              0.1% chondroitin sulfate and animal protein” refers to a mixture of chondroitin sulfate                         
              and animal protein, present in the gel at about 0.1% by weight.  The gel may also                               
              include citric acid and triethanolamine.                                                                        
                      Cornell describes “a non-cytotoxic wound hydrating gel comprising a) a                                  
              hydrocolloid mixture of sodium carboxymethylcellulose and sodium/calcium alginate,                              
              and b) and a preservative system” (column 2, lines 16-20).  “Hydrocolloids which can                            
              optionally be used [ ] additionally . . . include Carbopol, including Carbopol 940 [at                          
              about 0.5-0.75%],2 carrageenan, agar, and gelatin” while “[t]he preservative system                             
              comprises dimethylol dimethylhydantoin (DMDM hydantoin)” at about “0.05-0.1% by                                 
              weight (not 0.05-1% as asserted by the examiner on page 3 of paper no. 13) and “an                              
              antimicrobial agent and a mold and yeast inhibitor” (column 2, lines 46-60).  Cornell’s                         
              gel is anywhere from 87-97.9% deionized water, and may also contain 0.5%                                        
              triethanolamine, and as much as 10% propylene glycol or 10% glycerin. See Examples                              
              8 and 10.                                                                                                       
                      Andermann teaches that DMDM Hydantoin-containing formulations are “effective                            
              in the treatment of malconditions of the skin, including acne” and “may also be useful in                       


                      2 Carbopols® are acrylates/C10-30 alkyl acrylate crosspolymers, with the                                
              CTFA/INCI designation “carbomer.”                                                                               

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