Appeal No. 2003-1106
Application No. 09/825,896
25. A pharmaceutical composition comprising:
(i) an effective amount of a compound of formula I:
or a pharmaceutically acceptable salt or hydrate
thereof, wherein
R is selected from the group consisting of a C1-C9
straight or branched chain alkyl or C2-C9 straight or
branched chain alkenyl, C3 or C5 cycloalkyl, C5-C7
cycloalkenyl, and Ar1,
wherein said alkyl or alkenyl is optionally
substituted with C3-C8 cycloalkyl,
C1-C4 alkyl, C2-C4 alkenyl, or hydroxy,
wherein said cycloalkyl or cycloalkenyl is
optionally substituted with C1-C4 alkyl, C2-C4 alkenyl,
or hydroxy,
Ar1 is selected from the group consisting of 1-
naphthyl, 2-naphthyl, 2-indolyl, 3-indolyl, 2-furyl,
3-furyl, 2-thiazolyl, 3-thienyl, 2-pyridyl, 3-pyridyl,
4-pyridyl, and phenyl,
wherein said Ar1 has one to three substituents
which are independently selected from the group
consisting of hydrogen, halo, hydroxyl, nitro,
trifluoromethyl, C1-C6 straight or branched alkyl or
C2-C6 straight or branched alkenyl, C1-C4 alkoxy or C2-
C4 alkenyloxy, phenoxy, benzyloxy, and amino;
x is selected from the group consisting of
oxygen, sulfur, methylene, and H2;
Y is selected from the group consisting of oxygen
and NR2, wherein R2 is hydrogen or C1-C8 alkyl; and
Z is selected from the group consisting of C2-C6
straight or branched chain alkyl or C2-C6 straight or
branched chain alkenyl, and Ar2,
wherein the C2-C6 straight or branched alkyl is
substituted in one or more positions with Ar1 as
defined above, C3-C8 cycloalkyl, or cycloalkyl
connected by a C1-C6 alkyl or C2-C6 alkenyl;
2
Page: Previous 1 2 3 4 5 6 7 8 9 10 Next
Last modified: November 3, 2007