Ex Parte Heller - Page 3



              Appeal No. 2003-1716                                                                   Page 3                 
              Application No. 09/946,205                                                                                    
                     Initially, we note applicant's statement that "[c]laims 1-7 are presented for                          
              appeal.  Claims 1-7 stand or fall together with respect to the rejection made by the                          
              Patent Office" (Paper No. 10, page 3).  Accordingly, for the purposes of this appeal, we                      
              shall treat dependent claims 2 through 5 as standing or falling together with                                 
              independent claim 1 in considering the rejection under 35 U.S.C. § 102(b).  We shall                          
              treat dependent claims 2 through 7 as standing or falling together with independent                           
              claim 1 in considering the rejection under 35 U.S.C. § 103(a).                                                
                                                       Section 102                                                          
                     Lukas-Laskey discloses a method for decreasing the mortality of patients                               
              suffering from congestive heart failure.  According to the Lukas-Laskey method, a                             
              specified carbazole compound, preferably carvedilol, is administered "in conjunction                          
              with one or more other therapeutic agents, said agents being selected from the group                          
              consisting of angiotensin converting enzyme (ACE) inhibitors, diuretics, and cardiac                          
              glycosides" (page 1, lines 17-20).  Lukas-Laskey identifies a preferred diuretic, hydro-                      
              chlorothiazide, at page 6, lines 11 and 12 ("the preferred diuretics of the present                           
              invention are hydrochlorothiazide furosemide or torasemide or any pharmaceutically                            
              acceptable salts thereof").                                                                                   
                     Further, Lukas-Laskey discloses that pharmaceutical compositions                                       
                     including carvedilol, alone or in combination with ACE inhibitors, or                                  
                     diuretics, or cardiac glycosides may be administered to patients according                             
                     to the present invention in any medically acceptable manner, preferably                                
                     orally [page 6, lines 27-30].                                                                          
              In another passage, Lukas-Laskey states that                                                                  
                     Alternatively, these compounds may be encapsulated, tableted or                                        
                     prepared in a [sic] emulsion or syrup for oral administration.                                         





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