Ex Parte TULLY et al - Page 9


                  Appeal No. 2003-0835                                                           Page 9                    
                  Application No. 09/419,371                                                                               

                         which possess the properties claimed, an assay for determining                                    
                         such levels and a mammalian testing paradigm for the assessment                                   
                         of such effects on long term memory.                                                              
                  Paper No. 6, pages 8-9.                                                                                  
                         The rejection also cites Smith5 to support the proposition that “several                          
                  aspects of long-term memory (LTM) as a complex phenomenon wherein the                                    
                  underlying neurochemical/biochemical/genetic substrates are not understood, in                           
                  particular when compared across species.”  Id. at 9.  In addition, according to the                      
                  rejection, Smith discloses that “experimental studies, paradigms and designs for                         
                  assessing and ‘measuring’ LTM varies widely across species; applicants’                                  
                  specification fails to provide support for experimental model used to assess LTM                         
                  in Drosophila as valid for assessing LTM in any mammal.”  Id.                                            
                         “[T]he PTO bears an initial burden of setting forth a reasonable                                  
                  explanation as to why it believes that the scope of protection provided by that                          
                  claim is not adequately enabled by the description of the invention provided in                          
                  the specification of the application; this includes, of course, providing sufficient                     
                  reasons for doubting any assertions in the specification as to the scope of                              
                  enablement.”  In re Wright, 999 F.2d 1557, 1561-62, 27 USPQ2d 1510, 1513                                 
                  (Fed. Cir. 1993).  See also In re Armbruster, 512 F.2d 676, 678, 185 USPQ 152,                           
                  153 (CCPA 1975) (“Section 112 does not require that a specification convince                             
                  persons skilled in the art that the assertions therein are correct.”).                                   



                                                                                                                           
                  5 Smith, Elements of Molecular Biology, Second Edition, John Wiley & Sons Ltd., pp. 419-443              
                  (1996).                                                                                                  





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