Ex Parte Barthelemy et al - Page 5


               Appeal No. 2003-2023                                                                                                   
               Application 09/581,440                                                                                                 

               latter drawn to perfluorobutyl methyl ether and a somewhat similar recitation of organic solvents                      
               for the formation of azeotrope-like compositions but without disclosure of esters containing                           
               4 carbon atoms, that is, acetate and propionate esters (cf. Flynn ‘812, col. 5, line 66, to col. 6,                    
               line 38, with Flynn ‘595, col. 5, lines 45-63), would also have made the substitution of the                           
               methyl ether for ethyl ether obvious (Paper No. 11, page 5; answer, pages 3-5).                                        
                       Appellants submit that the examiner’s position is based on hindsight because there is no                       
               disclosure of an azeotrope-like composition containing perfluorobutyl methyl ether and an ester                        
               in Flynn ‘812, pointing out that esters are disclosed in this reference only as suitable alkylating                    
               agents at col. 4, lines 32-44, and the listing of suitable solvents in Flynn ‘812 differs in this and                  
               other respects from the listing of solvents in Flynn ‘595 (brief, pages 8-11).  Thus, appellants                       
               argue that the fact that ester solvents are shown by Flynn ‘595 to be useful in forming azeotrope-                     
               like compositions with perfluorobutyl ethyl ethers does not suggest modifying the teachings of                         
               azeotrope-like compositions containing perfluorobutyl methyl ethers of Flynn ‘812 to include                           
               ethyl acetate (id., pages 11-12).                                                                                      
                       On this record, we agree with appellants.  In order to establish a prima facie case of                         
               structural obviousness on this record, the examiner must establish by scientific reasoning and/or                      
               objective evidence that adjacent members of the perfluorobutyl ether series would have been                            
               expected by one of ordinary skill in the art to have similar properties with respect to azeotrope-                     
               like compositions in view of the teachings of the Flynn references.  In this respect, we find no                       
               evidence advanced by the examiner other than the alleged general similarity between “methyl”                           
               and “ethyl” per se, and indeed, such a general statement alone does not provide the requisite                          
               evidence necessary to establish this position in view of the formation of azeotrope-like                               
               compositions with different sets of organic solvents for the perfluorobutyl methyl and ethyl                           
               ethers as disclosed by the respective Flynn references, wherein there is no disclosure of the                          
               formation of azeotrope-like composition with the perfluorobutyl methyl ether and esters                                
               containing 4 carbon atoms in Flynn ‘292.  See generally, In re Jones, 958 F.2d 347, 349-51,                            
               21 USPQ2d 1941, 1943-44 (Fed. Cir. 1992) (“Conspicuously missing from this record is any                               
               evidence, other than the PTO’s speculation (if it be called evidence) that one of ordinary skill in                    
                                                                                                                                      
               the part of this person. In re Sovish, 769 F.2d 738, 743, 226 USPQ 771, 774 (Fed. Cir. 1985).                          

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