Ex Parte HOFSTRAAT et al - Page 3




          Appeal No. 2004-0351                                                        
          Application No. 09/463,277                                                  


               We refer to the brief and reply brief and to the answer for            
          a complete discussion of the opposing viewpoints expressed by the           
          appellants and by the examiner concerning the above noted                   
          rejection.                                                                  
                                       OPINION                                        
               For the reasons which follow, we cannot sustain this                   
          rejection.                                                                  
               As acknowledged by the examiner, the appellants’ claimed               
          label distinguishes over the 2(MFP) compound of Verhey (e.g., see           
          the paragraph bridging pages 809-10) by requiring that the here             
          claimed bridge be an 8-azabicyclo [3,2,1] octane comprising                 
          group.  That is, the here claimed bridge is bicyclic whereas the            
          corresponding bridge of the 2(MFP) compound is monocyclic.  The             
          examiner relies upon the teachings of Krijnen to supply this                
          deficiency of Verhey.                                                       
               The Krijnen reference is a scientific study of through-bond            
          interaction on conformation and structure of certain piperidone             
          and tropanone derivatives.  As revealed in figures 2 and 3 on               
          page 4435 of this reference, the tropanone and piperidone                   
          derivatives are bicyclic and monocyclic respectively.  It is the            
          examiner’s ultimate conclusion that Krijnen would have suggested            
          modifying Verhey’s 2(MFP) compound to include a bicyclic, rather            

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