Ex Parte Wong et al - Page 5



                Appeal No. 2004-0450                                                                             Page 5                   
                Application No. 09/785,936                                                                                                

                        phosphatase enzyme; or 3) the formation of an aqueous slurry or mixture                                           
                        of vegetable protein material and an acid phosphatase enzyme or an                                                
                        enzyme preparation containing an acid phosphatase enzyme, where the                                               
                        acid phosphatase enzyme or enzyme preparation is present in the slurry                                            
                        or mixture in an amount of from about 0.1% to about 10% by weight of                                              
                        protein material (dry). [Appeal Brief, page 6]                                                                    


                                                          RNA Degradation                                                                 
                        The ‘343 patent does not explicitly mention RNA or the degradation of RNA.                                        
                Nonetheless, applicants acknowledge that                                                                                  
                        Commercially available protein concentrates and isolates . . . contain                                            
                        some impurities which are undesirable in products such as infant                                                  
                        formulas.  Specific impurities which are undesirable in vegetable protein                                         
                        isolates and concentrates include phytic acid, phytates, ribonucleic acids,                                       
                        ash, and minerals bound to phytic acid, phytates, or ribonucleic acids                                            
                        which are unavailable for human assimilation such as phosphorus,                                                  
                        calcium, chloride, iron, zinc, and copper.  It is desirable to provide                                            
                        methods for reducing the levels of these impurities in vegetable protein                                          
                        isolates and concentrates, particularly for use in products such as infant                                        
                        formulas. [Specification, page 1, lines 12 through 19]                                                            
                According to applicants, “[p]hytase enzyme compositions are not recognized to reduce                                      
                the levels of ribonucleic acid materials and associated minerals in vegetable protein                                     
                materials since the most common phytases . . . do not degrade the ribonucleic acid                                        
                structure.”  (Id., page 2, lines 26 through 29).                                                                          
                        Applicants have attached several publications to their Appeal Brief and Reply                                     
                Brief as support for this argument.  For example, according to applicants, the Leach                                      
                publication (Appendix C of the Brief) teaches that “one skilled in the art would not                                      
                expect phosphatases to degrade polymeric nucleotides such as ribonucleic acids”                                           
                (Appeal Brief, page 13, first full paragraph).  Also, the Cech patent (Appendix D of the                                  






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