Ex Parte SEED et al - Page 1




                            The opinion in support of the decision being entered today was not written                   
                                   for publication and is not binding precedent of the Board.                            


                         UNITED STATES PATENT AND TRADEMARK OFFICE                                                       
                                                     __________                                                          
                               BEFORE THE BOARD OF PATENT APPEALS                                                        
                                             AND INTERFERENCES                                                           
                                                     __________                                                          
                                                Ex parte BRIAN SEED,                                                     
                                  CHARLES ROMEO and WALDEMAR KOLANUS                                                     
                                                     __________                                                          
                                                Appeal No. 2004-1736                                                     
                                              Application No. 09/243,008                                                 
                                                     __________                                                          
                                                      ON BRIEF                                                           
                                                     __________                                                          
                 Before MILLS, GRIMES, and GREEN, Administrative Patent Judges.                                          
                 GREEN, Administrative Patent Judge.                                                                     

                                               DECISION ON APPEAL                                                        
                        This is a decision on appeal under 35 U.S.C. § 134 from the examiner’s                           
                 final rejection of claims 44-47, 51, 52, 72-75, 79, 100 and 101.  Claims 44 and 79                      
                 are representative of the subject matter on appeal, and read as follows:                                
                        44.     A cell which expresses at least two proteinaceous                                        
                        membrane-bound chimeric receptors,                                                               
                                the first of said receptors comprising (a) an extracellular                              
                        portion which is capable of specifically recognizing and binding a                               
                        target cell or a target infective agent, (b) a transmembrane portion                             
                        derived from a T cell receptor, a B cell receptor, or an Fc receptor                             
                        protein which, in the absence of an intracellular signalling domain,                             
                        is capable of signalling said cell to destroy a receptor-bound target                            
                        cell or a receptor-bound target infective agent, and (c) an                                      
                        intracellular domain that does not signal said cell to destroy a                                 






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