Appeal No. 2004-2079 Page 2
Application No. 09/754,958
Claim 17 is illustrative of the subject matter on appeal and is reproduced
below:
17. Compounds comprising structure of formula II or of formula III
A-B-D-C-D'- (Formula II)
A-B-D- and -D'-C (Formula III)
wherein
A is selected from the group consisting of functionalized polystyrene
based resins, polyacrylamide based polymers, polystyrene/
polydimethylacrylamide composites, PEGA resins, polystyrene-
polyoxyethylene based supports, polystyrene/divinylbenzene-PEG
graft copolymers, PEG-polystyrene graft polymeric supports, glass
surfaces, functionalized surfaces, materials grafted with
functionalized surfaces, and polyethylenglycol;
B is a linker allowing cleavage of fluorescent conjugates of formula II
or of formula-III for liberation of the D and C containing fragments;
C is a compound selected from formula (I)
(I)
wherein
one of the radicals R1 or R2 and one of the radicals R3 or R4 is
hydrogen and the other is independently -COOH, -COOR7, -CONH2,
-CONH(CH2)nOH, -CONR8R9, -CH2OH, -CH2NH2, -NO2, NR10R11,
NHCOR12, Cl, Br, F, -CF3, -N=C=O, -N=C=S, -SO3H,
-SO2NH(CH2)nNH2, (C1-C4)alkyl, (C1-C16)-alkyl substituted at the
terminal carbon with -COOH, -COOR7, -CONH2, -CONR8R9,
-CONH(CH2)nOH, -CH2OH, -CH2NH2, -N=C=O, -N=C=S, -SO3H,
-SO2NH(CH2)nNH2, -CONH(CH2)nNH2, and the -NH2 group could also
be substituted by (C1-C4) alkyl or a commonly used amino protecting
group;
and one of the radicals R5 or R6 is hydrogen and the other is
hydrogen, halogen, -NO2, -NR10R11, -NHCOR12, (C1-C4) alkyl, (C1-
C16)-alkyl substituted at the terminal carbon with -COOH,
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