Ex Parte Rose et al - Page 5




             Appeal No. 2005-0978                                                                              
             Application No. 09/983,232                                                                        
             35 U.S.C. § 103                                                                                   
                   Claims 54-56 stand rejected under 35 U.S.C.  §103(a), as unpatentable over                  
             Petterson.                                                                                        
                   In rejecting claims under 35 U.S.C. § 103, the examiner bears the initial burden            
             of presenting a prima facie case of obviousness.  See In re Rijckaert, 9 F.3d 1531,               
             1532, 28 USPQ2d 1955, 1956 (Fed. Cir. 1993).   It is well-established that the                    
             conclusion that the claimed subject matter is prima facie obvious must be supported by            
             evidence, as shown by some objective teaching in the prior art or by knowledge                    
             generally available to one of ordinary skill in the art that would have led that individual to    
             combine the relevant teachings of the references to arrive at the claimed invention.  See         
             In re Fine, 837 F.2d 1071, 1074, 5 USPQ2d 1596, 1598 (Fed. Cir. 1988).                            
                   According to the examiner (Answer, page 4):                                                 
                   Pettersen et al. teach a method of inhibiting the growth of a cancer cell                   
                   (e.g. lung carcinoma) in which the method comprises contacting the                          
                   cancer cell with a pharmaceutical composition comprised of compounds                        
                   defined by formula l (see Col. 2, lines 40-67; Col. 3 thru Col. 4, lines 1-29;              
                   Col. 16 and 17).  The difference between the presently claimed invention                    
                   and what is taught by the Petterson et al. reference is that the Pettersen et               
                   al. reference does not specifically recite compounds according to Formula                   
                   II A of the present claims.  However, Pettersen et al. do generally teach a                 
                   group of compounds, represented by their formula I, in which some of the                    
                   presently claimed species are encompassed.                                                  


             The examiner concludes “[i]t would have been prima facie obvious to one having                    
             ordinary skill in the art, in view of the Pettersen et al. reference, to arrive at the presently  
             claimed invention because Pettersen et al. teach a similar method of inhibiting the               
             growth of a cancer cell with a group of compounds is [sic, in] which some of the possible         
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