Ex Parte Eckert et al - Page 4




               Appeal No. 2006-0767                                                                                               
               Application No. 09/962,258                                                                                         


               Grignard reagent is present in a high concentration at the beginning of the reaction and                           
               then steadily decreases (Brief, page 4).  Appellants further argue that the concentration                          
               of a reactant in the reaction mixture is “known to have a very strong influence” on the                            
               course of the reaction (id.).                                                                                      
                      Appellants’ arguments are not persuasive.  Appellants have not presented any                                
               probative evidence that the concentrations of Grignard reagent markedly differ in the                              
               prior art and claimed reactions, nor have appellants established that the concentration                            
               of the Grignard reagent is “known” to have a “very strong” influence on the reaction.                              
               Attorney argument generally cannot take the place of evidence.  See In re Scarborough,                             
               500 F.2d 560, 566, 182 USPQ 298, 302 (CCPA 1974).  We note that the claims on                                      
               appeal do not specify that the concentration of the Grignard reagent is “always at a very                          
               low level,” or even how the Grignard reagent is introduced.  We also note that Lipshutz                            
               clearly teaches that the Grignard reagent “was slowly added” (page 165, section 2.2).                              
               Accordingly, we find no basis or support for appellants’ arguments concerning the                                  
               concentration of the Grignard reagent in the reaction mixture (see the Answer, page 4).                            
                      Appellants argue that one of ordinary skill in the art, following the teachings of                          
               Lipshutz, would not have been motivated to modify Lipshutz, practice appellants’                                   
               invention, and expect the results appellants have obtained (Brief, page 5).                                        
                      Appellants’ arguments are not persuasive.  In reviewing the examiner’s                                      
               obviousness analysis, we first must correctly construe the claim language to define the                            

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