Ex Parte Pahl et al - Page 2




              Appeal No. 2006-1391                                                                                        
              Application No. 10/168,806                                                                                  

                     According to appellants, the invention is directed to a cross-flow filtration cassette               
              having at least one two-ply microporous separation membrane wherein the plies of the                        
              two-ply membrane physically lie on top of one another, are joined at their peripheries by                   
              spacers but not bonded together, and the pores of the separation membrane are sized                         
              such that the average pore size of the front side ply is 1.3 to 5 times the average pore                    
              size of the back side ply (Brief, pages 2-3).  Independent claim 1 is illustrative of the                   
              invention and is reproduced below:                                                                          
                            1. A cross-flow filtration cassette having a feed inlet and feed flow                         
                     channel; a permeate flow channel and a permeate outlet; a retentate outlet; and                      
                     at least one    two-ply microporous separation membrane having a front side ply                      
                     facing said feed channel and a back side ply facing said permeate channel                            
                     wherein said plies physically lie on top of one another and are joined at their                      
                     peripheries by spacers but are not bonded together in the area between said                          
                     spacers, wherein the flow of liquid feed through said separation membrane is                         
                     tangential over the surface of said separation membrane and the flow of                              
                     permeate through said separation membrane is from the front side ply to the                          
                     back side ply, and wherein the pores of said separation membrane are sized                           
                     such that the average pore size of said front side ply is 1.3 to 5 times the average                 
                     pore size of said back ply.                                                                          
                     The examiner has relied upon the following references as evidence of                                 
              obviousness:                                                                                                

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